唐宏武课题组

培育杰出人才

课题组大合照

培育杰出人才

研究进展

Abstract: Optical tweezers are considered a tool for trapping and measuring forces on single molecules and small particles. Current research mainly focuses on measuring force spectral information of particles suspended in solution. However, the viscoelastic environment within the cell presents additional challenges for the in situ calibration of force spectroscopy data. To address this issue, we used ...

2025-05-16

Optical trapping of a single virus in a host cell based on active-passive calibration for trap stiffness

ACS Nano

Abstract: Endothelial cells (ECs) regulate vascular function by converting mechanical forces into biochemical signals; however, the molecular mechanisms of pN-scale mechanotransduction remain elusive. Here, we develop an optical tweezer-integrated confocal microscopy system that allows precise, noninvasive manipulation of the cell membrane localization with mechanical stimuli within the 0–100 pN range ...

2025-04-08

Optical Tweezer-Driven Mechanotransduction: Probing pN-Scale Forces and Calcium-Mediated Redox Signaling in Single Endothelial Cells

ACS Nano

Abstract: Mutation in oncogene KRas plays a crucial role in the occurrence and progression of numerous malig- nant tumors. Malignancy involves changes in cell mechanics for extensive cellular deformation during metastatic dissemination. We hypothesize that oncogene KRas mutations are intrinsic to alterations in cellular mechanics that promote malignant tumor generation and progression. Here, we demonstrate ...

2024-06-27

Tunneling nanotubes mediate KRas transport: Inducing tumor heterogeneity and altering cellular membrane mechanical properties

Acta Biomater

Abstract: An optical manipulation method to activate the aggregation-induced emission (AIE) of Au(I)-glutathione (Au(I)-GSH) complexes is presented. First, the well-known AIE-type Au(I)-GSH complexes with a solid emission wavelength of 570 nm are synthesized. At the beginning of the focusing a 1064 nm continuous-wave (CW) laser at the interface of Au(I)-GSH complexes solution, its luminescence is hardly ...

2024-01-15

Aggregation-Induced Emission (AIE) of Au(I)-GSH Complexes is Activated by Optical Manipulation and Exhibits Surprising 780 nm Emission

Adv. Opt. Mater

Abstract: Although great headway has been made in DNAzyme-based detection of Pb2+, its adaptability, sensitivity, and accessibility in complex media still need to be improved. For this, we introduce new ways to surmount these hurdles. First, a spherical nucleic acid (SNA) fluorescence probe (Au nanoparticles-DNAzyme probe) is utilized to specifically identify Pb2+ and its suitability for precise detection ...

2024-01-01

Amplification of the Fluorescence Signal with Clustered Regularly Interspaced Short Palindromic Repeats-Cas12a Based on Au Nanoparticle-DNAzyme Probe and On-Site Detection of Pb2+ Via the Photonic Crystal Chip

ACS Sensors

Abstract: Abstract：Optical tweezers use the momentum of photons to capture and manipulate particles in a noncontact way. Although related techniques have been widely used in biology and materials, the research on viruses is still relatively limited. It is hard to optically trap viruses because trap stiffness is rather low and the size of viruses are too small. Here, we used an optical tweezers system ...

2023-11-15

Boosting optical trapping a single virus by quantum dots tagging increases virus polarizability and trap stiffness

ACS Appl. Mater. Interfaces

新闻公告

唐宏武课题组在单细胞力学研究领域取得新进展

新闻网讯（通讯员唐晖）近日，武汉大学化学与分子科学学院唐宏武教授团队在ACS Nano发表两篇研究论文，分别为“Optical trapping of a single virus in a host cell based on active-passive calibration for trap stiffness”“Optical Tweezer-Driven Mechanotransduction: Probing pN-Scale Forces and Calcium-Mediated Redox Signaling in Single Endothelial Cells”。2021级博士研究生徐大地为第一篇论文的第一作者，2022级博士研究生李煜垚和高等研究院博士生李浩冬为第二篇论文的共同第一作者。...

培育杰出人才

课题组大合照

培育杰出人才

研究进展

Optical trapping of a single virus in a host cell based on active-passive calibration for trap stiffness

Optical Tweezer-Driven Mechanotransduction: Probing pN-Scale Forces and Calcium-Mediated Redox Signaling in Single Endothelial Cells

Tunneling nanotubes mediate KRas transport: Inducing tumor heterogeneity and altering cellular membrane mechanical properties

Aggregation-Induced Emission (AIE) of Au(I)-GSH Complexes is Activated by Optical Manipulation and Exhibits Surprising 780 nm Emission

Amplification of the Fluorescence Signal with Clustered Regularly Interspaced Short Palindromic Repeats-Cas12a Based on Au Nanoparticle-DNAzyme Probe and On-Site Detection of Pb2+ Via the Photonic Crystal Chip

Boosting optical trapping a single virus by quantum dots tagging increases virus polarizability and trap stiffness

新闻公告

唐宏武课题组在单细胞力学研究领域取得新进展

武汉大学唐宏武教授团队ACS Nano | 光镊驱动的机械转导：单细胞水平探测内皮细胞pN级力在Ca²⁺介导氧化还原信号的传导

ACS Nano | 武汉大学唐宏武教授团队：光镊捕获宿主细胞内单个病毒：主动-被动校正法校准细胞内病毒的光阱刚度

课题组2021届博士学位论文答辩顺利完成

课题组2023届硕士学位论文答辩顺利完成